Full text is available at the source.
Abstract
Disruption or reprogramming of circadian rhythms is closely associated with cancer initiation, progression, and treatment response.
- Circadian rhythms regulate key physiological and behavioral processes like sleep and hormone secretion.
- Endogenous biological clocks synchronize with environmental light-dark cycles.
- Dysregulation of core clock genes may lead to abnormal cell growth and impaired DNA repair.
- Altered metabolism and disrupted immune responses could result from disturbances in normal cellular rhythms.
- Strategies to modulate clock genes include behavioral changes, pharmacological treatments, and gene-editing techniques.
Simplified