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Abstract
Circadian rhythms regulate critical biological functions and may be linked to aging and neurodegenerative diseases.
- Circadian rhythms operate on a 24-hour cycle and influence sleep, cognitive function, immune responses, and hormone secretion.
- Aging is associated with changes in sleep patterns and may disrupt circadian rhythms, potentially worsening neurodegenerative diseases like Parkinson's and Alzheimer's.
- Core CLOCK genes, such as BMAL1 and Per2, play a regulatory role in circadian rhythms and their relationship with aging.
- Circadian misalignment is linked to metabolic disorders, including obesity, diabetes, and cardiovascular disease.
- Therapeutic strategies targeting circadian pathways could include pharmacological agents and lifestyle modifications to promote healthy aging.
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