Circadian rhythms and mood disorders: Time to see the light

Oct 20, 2023Neuron

How Body Clocks Relate to Mood Disorders and the Role of Light

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Abstract

Mood disorders are strongly associated with abnormal sleep and circadian rhythms.

  • Disruptions to light/dark cycles and sleep/wake patterns may precipitate episodes of mood disorders.
  • Specific circadian phenotypes are linked to various mood disorders, including seasonal affective disorder, major depressive disorder, and bipolar disorder.
  • Neuronal mechanisms connect the circadian clock with mood regulation.
  • Therapies targeting the circadian system have shown therapeutic potential in some cases.
  • Current knowledge could aid in developing individually designed treatments for mood disorders.

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