Research progress and future directions in circadian rhythms for uterine‑related diseases (Review)
Recent advances and future possibilities in body clock rhythms linked to uterine diseases
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Abstract
Circadian rhythms in the uterus are regulated by clock genes that exhibit phasic changes, which are lost after decidualization.
- Clock genes in the endometrium show rhythmic expression that is altered post-decidualization.
- Rhythmic expression of clock genes in the myometrium is linked to uterine contractions and the timing of labor.
- Estrogen and progesterone are associated with modulation of core clock genes and the decidualization process.
- Melatonin, a key hormone from the central clock, influences the uterine environment and may affect delivery timing.
- Disruption of circadian rhythms is linked to conditions such as endometriosis, endometrial cancer, and menstrual disorders.
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