The Body's Internal Clock and Risk of Long-Term Kidney Disease: Population Evidence

Chronic kidney disease (CKD) affects roughly 10% of the world's population.

• Disruption of the circadian system may contribute to impaired kidney function and increased CKD risk.
• Evidence suggests that shift work, evening chronotype, prolonged social jetlag, and both short and long sleep duration are associated with elevated CKD risk.
• A total of 34 studies were reviewed, focusing on various factors such as shift work, artificial light at night, melatonin, and sleep health.
• Future research may benefit from standardized approaches and improved measures to clarify causal pathways related to circadian factors and CKD.

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