Clarithromycin reduces contractions in isolated human uterine muscle regardless of the trigger

Clarithromycin dose dependently inhibited the amplitude of contractions in human myometrial strips.

• The study investigated the effects of clarithromycin on oxytocin, prostaglandin F2alpha, and KCl-induced contractions of human myometrium.
• Human myometrial strips were obtained from pregnant women undergoing elective Cesarean section.
• Clarithromycin reduced contraction amplitude regardless of the stimulus applied.
• Pre-treatment with apamin blocked the inhibitory effects of clarithromycin on contraction amplitude and frequency.
• These findings suggest that clarithromycin may have a direct inhibitory effect on human myometrial contractions.

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