Clarithromycin inhibits myometrial contractions in isolated human myometrium independent of stimulus.
Clarithromycin reduces contractions in isolated human uterine muscle regardless of the trigger
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Abstract
Clarithromycin dose dependently inhibited the amplitude of contractions in human myometrial strips.
- The study investigated the effects of clarithromycin on oxytocin, prostaglandin F2alpha, and KCl-induced contractions of human myometrium.
- Human myometrial strips were obtained from pregnant women undergoing elective Cesarean section.
- Clarithromycin reduced contraction amplitude regardless of the stimulus applied.
- Pre-treatment with apamin blocked the inhibitory effects of clarithromycin on contraction amplitude and frequency.
- These findings suggest that clarithromycin may have a direct inhibitory effect on human myometrial contractions.
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