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Comparison of the effects of nimesulide and 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl) phenyl-2(5H)-furanone (DFU) on contractions of isolated pregnant human myometrium
Comparison of nimesulide and DFU on contractions of isolated pregnant human uterine muscle
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Abstract
5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl) phenyl-2(5H)-furanone (DFU) is a more potent inhibitor of myometrial contractions than nimesulide.
- DFU and nimesulide both inhibited contractions in isolated pregnant human myometrial strips in a concentration-dependent manner.
- Significant effects on the amplitude and frequency of contractions were observed with both inhibitors at concentrations ranging from 10(-7) to 10(-4)M for amplitude and 10(-6) to 10(-4)M for frequency.
- DFU showed a greater inhibitory effect compared to nimesulide on contractions stimulated by KCl, oxytocin, and PGF(2alpha).
- The effects of both inhibitors were found to be significantly stronger on KCl-stimulated contractions compared to those stimulated by oxytocin and PGF(2alpha).
- No significant differences were noted between the maximal inhibition values of nimesulide and DFU across all tested tissues.
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