Erythromycin inhibits prostaglandin F2α‐induced contractions of myometrium isolated from non‐pregnant rats

Application of 1 mM erythromycin reduced the amplitude of PGF2alpha-induced contractions by 83%.

• Erythromycin was tested at concentrations of 0.01, 0.1, 0.2, 0.5, and 1 mM.
• Higher concentrations of erythromycin decreased both the frequency and amplitude of contractions induced by PGF2alpha.
• At 0.1, 0.2, 0.5, and 1 mM, erythromycin inhibited contraction amplitude by 27%, 38%, 54%, and 83%, respectively.
• The inhibition of contraction frequency at these concentrations was 10%, 16%, 32%, and 61%, respectively.
• Erythromycin's effect on PGF2alpha-induced contractions may have implications for treating primary dysmenorrhoea.

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