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Clock-controlled mir-142-3p can target its activator, Bmal1
The daily rhythm of mir-142-3p can regulate its own activator Bmal1
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Abstract
mir-142-3p directly targeted the 3'UTR of Bmal1 in human and mouse cells.
- Over-expression of mir-142-3p reduced Bmal1/BMAL1 mRNA and protein levels in 293ET and NIH3T3 cells.
- Knockdown of mir-142-3p increased Bmal1/BMAL1 mRNA and protein levels in U87MG cells.
- The expression of mir-142-3p oscillated in serum-shocked NIH3T3 cells.
- CLOCK/BMAL1 heterodimers directly controlled the expression of mir-142-3p in NIH3T3 cells.
- These findings suggest a potential negative feedback loop between mir-142-3p and the core clock genes.
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