Clock desynchronisation: why and how?

Rhythm desynchronization is associated with factors such as shift work, aging, and certain drugs.

• The internal clock in the suprachiasmatic nuclei regulates body rhythms based on environmental and genetic influences.
• Desynchronization occurs when the internal clock fails to align with external factors.
• Conflict between the internal clock and environmental cues may arise from shift work, transmeridian flights, and other disruptions.
• Age and psychiatric conditions can lead to inefficient synchronization of the internal clock.
• Circadian rhythm sleep disorders, including delayed or advanced sleep phase syndromes, can negatively impact clock function.
• Melatonin and bright light may aid in resynchronizing the internal clock after desynchronization.

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