Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections

Continuous Light Exposure May Promote Aging Changes in the Liver Linked to Low Melatonin Levels

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

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Abstract

Chronic continuous light exposure induces a pro-senescent and metabolically dysfunctional liver phenotype in rats.

  • Circadian rhythm disruption, linked to melatonin deficiency, negatively affects liver function.
  • Melatonin administration may reduce the severity of liver disorders caused by desynchronosis.
  • Most studied parameters showed statistically significant improvement with melatonin treatment.
  • Chronic continuous light exposure is associated with increased liver dysfunction and potential lifespan reduction.
  • The findings support the role of melatonin in correcting disturbances in liver homeostasis.

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