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Crosstalk between Components of Circadian and Metabolic Cycles in Mammals
Interaction between daily body clocks and metabolism in mammals
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Abstract
Metabolic processes in mammals may be closely intertwined with biological clocks and feeding rhythms.
- NAD-dependent enzymes, including Sirtuins and poly(ADP-ribose) polymerases, are potential links between metabolism and circadian rhythms.
- Certain transcription factors, such as CLOCK and NPAS2, may also influence metabolic regulation in relation to biological clocks.
- Nutrient-sensing transcriptional regulatory proteins might play a role in connecting a cell's metabolic state to circadian mechanisms.
- The relationship between metabolic regulators and circadian clock components could blur the lines between metabolic and circadian oscillations.
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