Cell metabolism

Interaction between daily body clocks and metabolism in mammals

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Metabolic processes in mammals may be closely intertwined with biological clocks and feeding rhythms.

  • NAD-dependent enzymes, including Sirtuins and poly(ADP-ribose) polymerases, are potential links between metabolism and circadian rhythms.
  • Certain transcription factors, such as CLOCK and NPAS2, may also influence metabolic regulation in relation to biological clocks.
  • Nutrient-sensing transcriptional regulatory proteins might play a role in connecting a cell's metabolic state to circadian mechanisms.
  • The relationship between metabolic regulators and circadian clock components could blur the lines between metabolic and circadian oscillations.

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