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Curcumin mitigates obesity-driven dysbiosis and liver steatosis while promoting browning and thermogenesis in white adipose tissue of high-fat diet-fed mice
Curcumin improves gut imbalance and fatty liver while boosting heat production in white fat of obese mice
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Abstract
Curcumin treatment reversed several negative effects of a high-fat diet in mice, including increased liver weight and metabolic dysfunction.
- High-fat diet (HFD) led to significant increases in body weight, liver weight, and markers of metabolic dysfunction in mice.
- Curcumin supplementation in HFD mice reversed many of these effects, except for liver weight.
- Curcumin inhibited the enlargement of fat cells and increased the expression of proteins related to fat metabolism and energy expenditure.
- Changes in gut microbiota composition were observed, with curcumin reducing pro-inflammatory bacteria and improving gut health.
- Curcumin is associated with enhanced insulin signaling and increased levels of the hormone adiponectin, which may contribute to its protective effects.
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