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Dec1 and CLOCK Regulate Na + /K + -ATPase β1 Subunit Expression and Blood Pressure
Dec1 and CLOCK control sodium-potassium pump subunit levels and blood pressure
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Abstract
DEC1 suppresses the expression of ATP1B1 and is associated with elevated blood pressure.
- DEC1 competes with the CLOCK:BMAL1 complex for binding to specific DNA elements that regulate the ATP1B1 gene.
- CLOCK:BMAL1 enhances the transcription of ATP1B1, which encodes a critical component of the sodium-potassium pump.
- Atp1b1 mRNA and protein levels exhibit a circadian rhythm that inversely correlates with blood pressure fluctuations.
- Dec1-deficient mice demonstrate increased Atp1b1 expression and lower blood pressure compared to wild-type mice.
- Clock-mutant mice display decreased Atp1b1 expression and higher blood pressure, indicating a role for CLOCK in blood pressure regulation.
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