Decreased VIP and VPAC2 receptor expression in the biological clock of the R6/2 Huntington's disease mouse

May 5, 2007Journal of molecular neuroscience : MN

Lower levels of a key brain chemical and its receptor in the internal clock of Huntington’s disease mice

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Abstract

A marked reduction in both VIP mRNA and VPAC2 receptor mRNA was found in the SCN of R6/2 mice.

  • R6/2 transgenic mice exhibit disrupted circadian rhythms alongside motor and cognitive dysfunctions.
  • Altered expression of circadian clock genes occurs in the suprachiasmatic nucleus, the main circadian pacemaker in the brain.
  • Decreased levels of vasoactive intestinal polypeptide (VIP) and its receptor VPAC2 coincide with circadian rhythm disruption.
  • No neuronal loss in the SCN was observed, suggesting changes in VIP and VPAC2 expression are not due to cell death.
  • Impaired VIPergic signaling may contribute to circadian rhythm disruption in R6/2 mice.

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