Biological psychiatry

DNA methylation patterns showing epigenetic differences in deep brain areas of people with PTSD

Updated

Abstract

Significant differential methylation was found near 195 genes associated with PTSD.

  • Epigenetic changes in DNA methylation may link environmental trauma exposure to gene expression alterations in the brain.
  • A cell type-specific DNA methylation atlas was constructed to detail changes in PTSD across six different cell types.
  • Methylation levels in the MAD1L1, ELFN1, and WNT5A genes are significant in PTSD patients who responded to ketamine treatment.
  • Comparative analysis with major depressive disorder patients highlighted unique methylation patterns in those with PTSD.

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Funding

Competing interests

COMPETING INTERESTS. J.H.K. has consulting agreements (less than US$10,000 per year) with the following: Aptinyx, Inc. Biogen, Idec, MA, Bionomics, Limited (Australia), Boehringer Ingelheim International, Epiodyne, Inc., EpiVario, Inc., Janssen Research & Development, Jazz Pharmaceuticals, Inc., Otsuka America Pharmaceutical, Inc., Spring Care, Inc., Sunovion Pharmaceuticals, Inc.; is the co-founder for Freedom Biosciences, Inc.; serves on the scientific advisory boards of Biohaven Pharmaceuticals, BioXcel Therapeutics, Inc. (Clinical Advisory Board), Cerevel Therapeutics, LLC, Delix Therapeutics, Inc., Eisai, Inc., EpiVario, Inc., Jazz Pharmaceuticals, Inc., Neumora Therapeutics, Inc., Neurocrine Biosciences, Inc., Novartis Pharmaceuticals Corporation, PsychoGenics, Inc., Takeda Pharmaceuticals, Tempero Bio, Inc., Terran Biosciences, Inc..; has stock options with Biohaven Pharmaceuticals Medical Sciences, Cartego Therapeutics, Damona Pharmaceuticals, Delix Therapeutics, EpiVario, Inc., Neumora Therapeutics, Inc., Rest Therapeutics, Tempero Bio, Inc., Terran Biosciences, Inc., Tetricus, Inc.; and is editor of Biological Psychiatry with income greater than $10,000. All other authors report no biomedical financial interests or potential conflicts of interest.
PubMed

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