DOUBLETIME Plays a Noncatalytic Role To Mediate CLOCK Phosphorylation and Repress CLOCK-Dependent Transcription within the Drosophila Circadian Clock

DBT catalytic activity is not required for CLK phosphorylation or transcriptional repression.

• DBT is involved in the phosphorylation of the transcription factor CLK and the repressor PER within the circadian clock of fruit flies.
• The phosphorylation of PER is not necessary for the repression of CLK-dependent transcription.
• DBT may recruit other kinases to phosphorylate CLK, leading to transcriptional repression.
• The mechanisms observed in Drosophila could be similar in mammals due to the conservation of PER, DBT, and CLK functions.

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