Full text is available at the source.
Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice
Liver changes after 5 weeks of alcohol in mice lacking a key enzyme for alcohol breakdown
AI simplified
Abstract
Ethanol intake in mice lacking functional ALDH2 led to a decrease in serum alanine aminotransferase (ALT) levels.
- Mice with inactive ALDH2 showed a clear decrease in serum ALT levels when fed ethanol.
- In contrast, serum ALT levels remained unchanged in mice with functional ALDH2.
- The decrease in ALT levels was associated with lower oxidative stress and reduced tumor necrosis factor-alpha secretion in liver tissue.
- Malondialdehyde and phospho extracellular signal-regulated kinase 2 levels in the liver correlated with ALT levels.
AI simplified