Pharmacogenetics and genomics

Liver changes after 5 weeks of alcohol in mice lacking a key enzyme for alcohol breakdown

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Updated

Abstract

Ethanol intake in mice lacking functional ALDH2 led to a decrease in serum alanine aminotransferase (ALT) levels.

  • Mice with inactive ALDH2 showed a clear decrease in serum ALT levels when fed ethanol.
  • In contrast, serum ALT levels remained unchanged in mice with functional ALDH2.
  • The decrease in ALT levels was associated with lower oxidative stress and reduced tumor necrosis factor-alpha secretion in liver tissue.
  • Malondialdehyde and phospho extracellular signal-regulated kinase 2 levels in the liver correlated with ALT levels.

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