Alcohol (Fayetteville, N.Y.)

One dose of alcohol lowers a liver enzyme gene in mice lacking a key aldehyde-processing enzyme

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Acetaldehyde metabolism is significantly impaired in individuals with the *ALDH22** polymorphism.

  • ALDH2*2 is common among individuals of East Asian descent and affects ethanol metabolism.
  • CYP2E1, a cytochrome P450 enzyme, is linked to increased oxidative stress and carcinogen activation.
  • Ethanol administration influences CYP2E1 gene expression in liver tissue.
  • In mice with normal ALDH2, CYP2E1 mRNA levels increased 12 hours after ethanol administration.
  • Mice lacking functional ALDH2 showed a significant decrease in CYP2E1 mRNA levels after the same treatment.
  • These findings indicate that inactive ALDH2 may downregulate CYP2E1 expression following ethanol exposure.

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