Missing aldehyde dehydrogenase reduces liver oxidative stress after a single alcohol dose in mice

Levels of malondialdehyde were significantly lower in Aldh2-/- mice than in Aldh2+/+ mice at 12 hours after ethanol administration.

• Aldh2 knockout mice demonstrate different metabolic responses to ethanol compared to normal mice.
• Ethanol administration leads to oxidative stress, indicated by malondialdehyde levels, in liver tissue.
• Higher levels of glutathione, an antioxidant, were observed in Aldh2-/- mice at 6 and 12 hours post-ethanol administration.
• The absence of ALDH2 may reduce ethanol-induced oxidative stress in liver tissue.

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