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Lack of aldehyde dehydrogenase ameliorates oxidative stress induced by single-dose ethanol administration in mouse liver
Missing aldehyde dehydrogenase reduces liver oxidative stress after a single alcohol dose in mice
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Abstract
Levels of malondialdehyde were significantly lower in Aldh2-/- mice than in Aldh2+/+ mice at 12 hours after ethanol administration.
- Aldh2 knockout mice demonstrate different metabolic responses to ethanol compared to normal mice.
- Ethanol administration leads to oxidative stress, indicated by malondialdehyde levels, in liver tissue.
- Higher levels of glutathione, an antioxidant, were observed in Aldh2-/- mice at 6 and 12 hours post-ethanol administration.
- The absence of ALDH2 may reduce ethanol-induced oxidative stress in liver tissue.
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