Changing Patterns of Aging-Related Genes Highlight IGFBP7 and CDKN1A as Markers for Aging Fibroblast Groups in Different Tissues
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Abstract
Elevated expression of individual SASP genes was characterized through single-cell RNA sequencing data from senescent cells.
- The senescence-associated secretory phenotype (SASP) is linked to age-related diseases such as cancer and cardiovascular disorders.
- Single-cell RNA sequencing revealed heterogeneity in SASP gene expression among mature senescent cells.
- Temporal variations in SASP expression were observed across early and mature senescent states in human lung fibroblast cells.
- A framework was developed to quantify SASP gene expression dynamics using integrated gene sets.
- SASP scores identified senescent fibroblasts in various human tissues, highlighting p21 and p16 as consistently upregulated markers.
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Competing interests
The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.
PubMed