Entrainment of Circadian Rhythms Depends on Firing Rates and Neuropeptide Release of VIP SCN Neurons

Jul 19, 2018Neuron

Circadian Rhythm Timing Depends on Activity and Chemical Signals of Key Brain Clock Neurons

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Abstract

Approximately 10% of suprachiasmatic nucleus neurons express vasoactive intestinal polypeptide (VIP).

  • VIP neurons exhibit circadian rhythms in their firing rates over a 3-day period.
  • Two classes of instantaneous firing activity were identified in VIP neurons.
  • High-frequency stimulation of VIP neurons alters gene expression rhythms in laboratory settings.
  • In living organisms, high-frequency activation of VIP neurons quickly adjusts circadian locomotor rhythms.
  • Increased firing frequency of VIP neurons leads to the release of VIP, which may synchronize molecular and behavioral circadian rhythms.

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