Neuron

Circadian Rhythm Timing Depends on Activity and Chemical Signals of Key Brain Clock Neurons

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Approximately 10% of suprachiasmatic nucleus neurons express vasoactive intestinal polypeptide (VIP).

  • VIP neurons exhibit circadian rhythms in their firing rates over a 3-day period.
  • Two classes of instantaneous firing activity were identified in VIP neurons.
  • High-frequency stimulation of VIP neurons alters gene expression rhythms in laboratory settings.
  • In living organisms, high-frequency activation of VIP neurons quickly adjusts circadian locomotor rhythms.
  • Increased firing frequency of VIP neurons leads to the release of VIP, which may synchronize molecular and behavioral circadian rhythms.

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