The Exosome Regulates Circadian Gene Expression in a Posttranscriptional Negative Feedback Loop

FFC binds frq RNA and interacts with the exosome to regulate RNA decay.

• FRQ and FRH form the FFC complex, which represses frq transcription.
• frq RNA stability is highest when FRQ levels are low, suggesting a rhythmic pattern.
• Silencing RRP44, a component of the exosome, increases frq RNA levels and disrupts clock function.
• RRP44 is identified as a clock-controlled gene and is regulated by the WHITE COLLAR complex.
• The findings indicate that FFC and the exosome may function in a posttranscriptional feedback loop affecting circadian rhythms.

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