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Accelerating discovery: A novel flow cytometric method for detecting fibrin(ogen) amyloid microclots using long COVID as a model
A new blood test method to detect tiny protein clots linked to long COVID
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Abstract
Imaging flow cytometry revealed a significantly increased concentration and size of amyloid microclots in Long COVID patients.
- Long COVID is associated with hypercoagulability, leading to the formation of amyloid microclots that resist breakdown.
- Previous methods lacked statistical robustness and rapid throughput for assessing microclot presence.
- The current study shows that imaging flow cytometry can accurately identify variations in size and fluorescence of microclots in Long COVID patients compared to controls.
- This technique enhances the accuracy of microclot detection beyond conventional flow cytometry, which has been widely used in clinical settings.
- Results suggest that conventional flow cytometry could also effectively detect microclots in Long COVID and related conditions.
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