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Fluoxetine Modulates the Circadian Biological Clock via Phase Advances of Suprachiasmatic Nucleus Neuronal Firing
Fluoxetine shifts the body's internal clock by advancing nerve activity in the brain's time-keeping center
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Abstract
Fluoxetine (10 microm) induced significant phase advances in circadian rhythms when combined with L-tryptophan (0.5 microm).
- Serotonin is known to influence circadian rhythms, suggesting a possible link with SSRIs.
- Extracellular recordings from suprachiasmatic nucleus neurons were used to assess circadian activity changes.
- Robust phase advances in circadian rhythms were observed following fluoxetine treatment.
- The presence of L-tryptophan was necessary to maintain serotonin levels for these effects.
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