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A GABAergic Mechanism Is Necessary for Coupling Dissociable Ventral and Dorsal Regional Oscillators within the Circadian Clock
A GABA system is needed to connect separate timing signals in different parts of the body’s internal clock
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Abstract
Bimodal patterns of spontaneous impulse activity were observed in the dorsal and ventral suprachiasmatic nucleus (SCN) after a 6 hr delay of the light schedule.
- A separate fast-resetting oscillator exists in the ventral SCN, while a distinct slow-resetting oscillator is found in the dorsal SCN.
- Continuous application of the GABA(A) antagonist bicuculline produced similar effects as cutting the SCN slices.
- Short application of bicuculline at different circadian phases increased electrical discharge in the ventral SCN but decreased it in the dorsal SCN.
- GABA is associated with transmitting phase information between the ventral and dorsal SCN oscillators.
- GABA may act excitatory in the dorsal SCN and inhibit neurons in the ventral SCN, suggesting asymmetrical interregional coupling within the SCN.
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