Current biology : CB

A GABA system is needed to connect separate timing signals in different parts of the body’s internal clock

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Bimodal patterns of spontaneous impulse activity were observed in the dorsal and ventral suprachiasmatic nucleus (SCN) after a 6 hr delay of the light schedule.

  • A separate fast-resetting oscillator exists in the ventral SCN, while a distinct slow-resetting oscillator is found in the dorsal SCN.
  • Continuous application of the GABA(A) antagonist bicuculline produced similar effects as cutting the SCN slices.
  • Short application of bicuculline at different circadian phases increased electrical discharge in the ventral SCN but decreased it in the dorsal SCN.
  • GABA is associated with transmitting phase information between the ventral and dorsal SCN oscillators.
  • GABA may act excitatory in the dorsal SCN and inhibit neurons in the ventral SCN, suggesting asymmetrical interregional coupling within the SCN.

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