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Mammalian circadian signaling networks and therapeutic targets
Daily Biological Clocks in Mammals and Possible Treatment Targets
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Abstract
The circadian timekeeping system in mammals relies on a hierarchical multi-oscillator network with the suprachiasmatic nuclei (SCN) as the central pacemaker.
- The SCN synchronizes to daily light-dark cycles, coordinating physiological and behavioral rhythms.
- Intercellular coupling in the SCN helps synchronize neuron oscillators and enhances system resilience.
- Recent advancements enable the development of cell-based clock models that lack strong coupling.
- These cell-based models are useful for target discovery and chemical biology applications.
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