Neuroscience research

How blocking cell connections affects daily rhythms of two key brain chemicals in the rat's internal clock

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Updated

Abstract

Circadian rhythms in arginine-vasopressin (AVP) and vasoactive intestinal polypeptide (VIP) release were maintained for 42 hours with octanol treatment.

  • AVP and VIP release rhythms were disrupted after 7 days of incubation with octanol or halothane.
  • Removal of gap junction blockers restored rhythmicity in AVP and VIP release.
  • Findings suggest that gap junction communication may play a role in connecting AVP and VIP neurons in the suprachiasmatic nucleus.

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