Effects of gap junction blocker on vasopressin and vasoactive intestinal polypeptide rhythms in the rat suprachiasmatic nucleus in vitro

Sep 21, 2000Neuroscience research

How blocking cell connections affects daily rhythms of two key brain chemicals in the rat's internal clock

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Abstract

Circadian rhythms in arginine-vasopressin (AVP) and vasoactive intestinal polypeptide (VIP) release were maintained for 42 hours with octanol treatment.

  • AVP and VIP release rhythms were disrupted after 7 days of incubation with octanol or halothane.
  • Removal of gap junction blockers restored rhythmicity in AVP and VIP release.
  • Findings suggest that gap junction communication may play a role in connecting AVP and VIP neurons in the suprachiasmatic nucleus.

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