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Genome sequencing progenies of magic mushrooms (Psilocybe subaeruginosa) identifies tetrapolar mating and gene duplications in the psilocybin pathway
Genome sequencing of magic mushroom offspring reveals four-part mating system and duplicated genes in psilocybin production
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Abstract
Mating in Psilocybe subaeruginosa is tetrapolar, with compatibility controlled by specific genetic loci.
- Compatibility is determined by a homeodomain locus featuring one copy each of HD1 and HD2.
- Mating is also influenced by a pheromone/receptor locus that has four homologs of the receptor gene STE3.
- Two additional pheromone/receptor loci homologous to STE3 do not regulate mating compatibility.
- Alleles in the psilocybin gene cluster were consistent among five siblings and likely homozygous in the parent.
- Psilocybe subaeruginosa possesses three copies of PsiH genes, but their role in psilocybin production remains unclear.
- Genetic improvement may necessitate access to diverse genetic resources, identification of trait-related genes, and strategies to prevent inbreeding.
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