The journal of cardiovascular agingApr 29, 2025

Finding treatment targets by studying the shared aging processes in heart failure

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗

Updated Mar 11, 2026

Abstract

Age is a major risk factor for heart failure, but emerging evidence suggests the biology of aging may be intervenable.

The biology of aging could be modified to address age-associated chronic diseases like heart failure.
Human omics has provided insights into the shared biological mechanisms of aging and heart failure.
Identifying relevant mechanisms of aging biology could lead to targeted therapies for heart failure.
A human-first approach in Geroscience may enhance the development of treatments for heart failure.

Simplified

Age is a major risk factor for heart failure, but one that has been historically viewed as non-modifiable. Emerging evidence suggests that the biology of aging is malleable, and can potentially be intervened upon to treat age-associated chronic diseases, such as heart failure. While aging biology represents a new frontier for therapeutic target discovery in heart failure, the challenges of translating Geroscience research to the clinic are multifold. In this review, we propose a strategy that prioritizes initial target discovery in human biology. We review the rationale for starting with human omics, which has generated important insights into the shared (patho)biology of human aging and heart failure. We then discuss how this knowledge can be leveraged to identify the mechanisms of aging biology most relevant to heart failure. Lastly, we provide examples of how this human-first Geroscience approach, when paired with rigorous functional assessments in preclinical models, is leading to early-stage clinical development of gerotherapeutic approaches for heart failure.

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Competing interests

Conflicts of interest Roh J receives research support from Keros Therapeutics, Genentech, and Amgen, all of which are unrelated to this work. All other authors declared that there are no conflicts of interest.

PubMed

Finding treatment targets by studying the shared aging processes in heart failure

Abstract

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Competing interests

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