Journal of gastroenterology and hepatology

Comparing Combined GLP-1 and SGLT2 Treatments to Single Therapy in Fatty Liver Disease and Type 2 Diabetes

Updated

Abstract

Glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors may provide cardiovascular and metabolic benefits.

  • The effects of combining GLP-1 receptor agonists and SGLT2 inhibitors in patients with metabolic dysfunction-associated steatotic liver disease and type 2 diabetes mellitus are not fully understood.
  • Both GLP-1 receptor agonists and SGLT2 inhibitors have shown individual benefits for cardiovascular health and metabolic function.
  • Further research is needed to clarify the comparative effectiveness of combination therapy versus monotherapy for this patient population.

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