Effects of GLP-1 Receptor Agonists on Gum and Supporting Mouth Tissues: A Broad Review of Evidence

Seven studies indicate that glucagon-like peptide-1 receptor agonists (GLP-1RAs) may reduce pro-inflammatory signaling in periodontal tissues.

• GLP-1RAs are associated with reduced alveolar bone resorption in preclinical models.
• Liraglutide was the most frequently studied GLP-1RA, appearing in four of the seven studies.
• The effects of GLP-1RAs on periodontal tissues may involve the NF-κB/MAPK and Wnt/β-catenin pathways.
• One study reported reduced inflammatory markers, but did not show a corresponding decrease in bone loss.
• Current evidence is limited to preclinical studies and does not support therapeutic use in clinical settings.

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