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Abstract
Extracellular loop 3 is identified as a conformational switch controlling transducer selectivity in glucagon-like peptide-1 receptors.
- Biased agonism may enhance incretin therapeutics.
- The structural determinants of signaling bias are not fully understood.
- A recent structure of the parathyroid hormone 1 receptor with beta-arrestin provides insights.
- Understanding this switch could enable the rational design of biased agonists.
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