Pharmacological research

How glucagon-like peptide-1 receptor activators affect muscle mass

Updated

Abstract

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are associated with significant weight loss and improved metabolic parameters.

  • GLP-1 RAs may unintentionally reduce skeletal muscle mass.
  • This reduction could exacerbate sarcopenic obesity, particularly in older or frail individuals.
  • Current data suggests a need for awareness of these potential adverse effects.
  • Strategies for mitigating muscle loss during GLP-1 RA therapy are discussed.

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Full Text

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Funding

Competing interests

Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Maciej Banach has received grant(s)/research support from Amgen, Daiichi-Sankyo, Mylan/Viatris, Sanofi and (last 36 months) has served as a consultant and/or received speaker’s fees from Adamed, Amgen, Exceed Pharma, Daiichi-Sankyo, Esperion, Kogen, KRKA, Lilly, MSD, Mylan/Viatris, NewAmsterdam Pharma, Novartis, Novo-Nordisk, Polpharma, Sanofi, Teva and Zentiva.
PubMed

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