REAL-WORLD ASSOCIATIONS BETWEEN GLUCAGON-LIKE PEPTIDE-1 RECEPTOR AGONIST USE AND DIABETIC RETINOPATHY ACCOUNTING FOR LONGITUDINAL GLYCEMIC CONTROL

May 7, 2025Retina (Philadelphia, Pa.)

Links Between Using GLP-1 Drugs and Diabetic Eye Disease Considering Blood Sugar Control Over Time

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Abstract

GLP-1 RA use was associated with a reduced risk of diabetic retinopathy, diabetic macular edema, and treatment-requiring conditions over 10 years.

  • Users of GLP-1 RAs had a 69% lower risk of developing diabetic retinopathy compared to non-users.
  • There was a 60% reduction in the risk of diabetic macular edema among those using GLP-1 RAs.
  • The risk of requiring treatment for diabetic retinopathy or diabetic macular edema was reduced by 82% in GLP-1 RA users.
  • The findings suggest that GLP-1 RAs may offer protective benefits against serious eye complications in diabetes.

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