Glucagon-like peptide-1 drugs may affect bowel cleaning for colonoscopy: A review and combined analysis

The inadequate bowel preparation rate was 2.10 times higher in patients using glucagon-like peptide-1 receptor agonists compared to controls.

• GLP-1 receptor agonists are associated with a higher rate of inadequate bowel preparation during colonoscopy.
• The odds ratio for inadequate bowel preparation in GLP-1RA users is 2.10, indicating a significant increase in risk.
• Mean Boston Bowel Preparation Scale scores are lower in the GLP-1RA group compared to the control group.
• The mean difference in Boston Bowel Preparation Scale score is -0.34, suggesting poorer bowel preparation quality with GLP-1RAs.

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