The impact of glucagon-like peptide-1 receptor agonists on the quality indicators of colonoscopy – a systematic review and meta-analysis

Mar 22, 2025Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

How glucagon-like peptide-1 receptor drugs affect colonoscopy quality measures

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Abstract

GLP-1 RA users showed a 6% higher rate of inadequate bowel preparation compared to controls.

  • In a review of six trials, involving 8778 GLP-1 RA users and 8290 controls, bowel preparation quality was assessed.
  • Total bowel preparation scores were lower among GLP-1 RA users, indicating poorer preparation.
  • Two of the studies noted an increased detection rate of adenomas or polyps in GLP-1 RA users, while one study reported no difference.
  • The findings suggest a potential association between GLP-1 RA use and inadequate bowel preparation for colonoscopy.

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