Glucoraphanin reduces obesity and insulin resistance by turning fat into calorie-burning tissue and lowering harmful gut-related toxins in mice

Glucoraphanin supplementation in high-fat diet-fed mice led to attenuated weight gain and improved insulin sensitivity.

• Weight gain was reduced in high-fat diet-fed mice receiving glucoraphanin compared to controls.
• Glucoraphanin treatment resulted in decreased liver fat accumulation and enhanced glucose tolerance.
• The beneficial effects of glucoraphanin were not observed in mice lacking the Nrf2 protein.
• Lower plasma levels of lipopolysaccharides were found in glucoraphanin-treated mice, indicating reduced metabolic endotoxemia.
• Changes in gut microbiome composition included a decrease in the abundance of the Desulfovibrionaceae family.
• Glucoraphanin increased energy expenditure and expression of a protein associated with fat burning in specific fat tissues.

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