Role of glycogen availability in sarcoplasmic reticulum Ca²⁺ kinetics in human skeletal muscle

Low muscle glycogen is associated with impairment in the release of Ca(2+) during exercise.

• Glycogen, stored in skeletal muscle, is a key energy source during physical activity.
• Depletion of glycogen may lead to muscle fatigue by reducing the availability of Ca(2+), crucial for muscle contraction.
• The findings suggest a link between energy usage in muscles and glycogen levels.
• Impaired Ca(2+) release could inhibit muscle performance during prolonged, exhausting exercise.

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