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Molecular study of gonad-inhibiting hormone in Penaeus monodon and its role in reducing egg yolk protein production using gene silencing

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Abstract

Pem-GIH cDNA is 861 bp in size and encodes a peptide that may inhibit vitellogenin synthesis in shrimp.

  • The cDNA for Pem-GIH includes a single open reading frame (ORF) of 288 bp.
  • Pem-GIH consists of a 17-residue signal peptide and a mature peptide region of 79 amino acids.
  • Transcript levels of Pem-GIH were found in multiple tissues, including the eyestalk and brain.
  • RNA interference targeting Pem-GIH led to decreased transcript levels in both eyestalk and abdominal nerve cord cultures.
  • A notable increase in vitellogenin transcript levels was observed in the ovaries of GIH-knockdown shrimp, suggesting that Pem-GIH negatively regulates vitellogenin expression.

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