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Grape Seed Proanthocyanidins Modulate the Hepatic Molecular Clock via MicroRNAs
Grape Seed Compounds May Influence the Liver's Internal Clock Through Small Genetic Regulators
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Abstract
250 mg kg of grape seed proanthocyanidins extract (GSPE) administered to Wistar rats modulated the expression of liver clock genes.
- GSPE influenced the expression of both Bmal1 and miR-27b-3p in the liver.
- Both Bmal1 and miR-27b-3p exhibited a in their expression.
- There was a negative interaction observed between Bmal1 and miR-27b-3p.
- GSPE may adjust the hepatic peripheral clock through miRNA modulation.
- In vitro studies indicated that Bmal1 is sensitive to GSPE, but this effect did not involve miR-27b-3p.
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Key numbers
250 mg/kg
GSPE Dose
Administered to Wistar rats before a 6-hour jet lag.
3 hours after lights off
miR-27b-3p Expression Increase
Observed significant upregulation in treated jet lag group.