Full text is available at the source.
Abstract
Dysbiosis may contribute to the development of neuropsychiatric and neurodegenerative disorders such as depression, Alzheimer's disease, and Parkinson's disease.
- The gut microbiota plays a significant role in brain function through the production of microbial metabolites.
- Short-chain fatty acids, tryptophan metabolites, and bile acids are key microbial metabolites influencing the gut-brain axis.
- Metabolic, immunological, and neuroendocrine signaling are important mechanisms in the gut-brain communication.
- Dietary components like fiber, polyphenols, and fermented foods can alter gut microbial composition and may affect brain health.
- Therapeutic strategies including probiotics, prebiotics, and fecal microbiota transplantation are emerging as potential interventions.
Simplified