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Gut Microbe-Derived Trimethylamine Shapes Circadian Rhythms Through the Host Receptor TAAR5
Gut Microbe Chemical Trimethylamine May Influence Body Clock Through a Specific Host Receptor
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Abstract
Mice lacking the host receptor for trimethylamine (TMA) show altered circadian rhythms and metabolic changes.
- Elevated levels of the gut microbe-derived metabolite trimethylamine N-oxide (TMAO) are linked to cardiometabolic disease risk.
- Dietary choline is converted by gut bacteria into TMA, which is then oxidized by the host to produce TMAO.
- Mice without the TMA receptor exhibit changes in gene expression related to circadian rhythms and metabolism.
- Genetic alterations that prevent TMA production or its oxidation also lead to fluctuations in circadian rhythms.
- These findings suggest a connection between gut bacteria, host metabolism, and circadian regulation.
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