How Gut Bacteria and Body Clock Interact to Affect Metabolism

The gut microbiome and circadian rhythms may interact to influence host physiology and metabolism.

• Both the gut microbiome and circadian rhythms are associated with various diseases, particularly metabolic disorders.
• Microbially derived mediators, such as short-chain fatty acids and bile acids, may serve as signals between the gut microbiome and host circadian clocks.
• Understanding the mechanisms of interaction between these systems remains a significant challenge.
• There are notable gaps in knowledge regarding the differences between animal and human models.
• Precise timed sample collection is necessary for advancing research in the circadian and microbiome fields.

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