Role of the microbiota in circadian rhythms of the host

Gut bacteria can influence the host's circadian gene expression through direct interactions and metabolites.

• Microbiota may affect circadian rhythms by interacting with immunoreceptors.
• Short-chain fatty acids and unconjugated bile acids are key metabolites produced by the microbiota.
• The microbiota mediates the relationship between diet and circadian rhythms.
• Diurnal variations in the microbiota's structure and function are influenced by the host and diet.
• Most findings are based on mouse models, suggesting a need for further research in human tissues.

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