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Abstract
Gut microbiota may significantly influence the efficacy of immunotherapy for colorectal cancer.
- Gut microbes modulate immune responses through various mechanisms, including immune cell activity and metabolite production.
- Specific gut microbes can enhance the effectiveness of immune checkpoint inhibitors by improving gut barrier function.
- The composition and diversity of gut microbiota are linked to the success of immunotherapies.
- Modifying gut microbiota could potentially improve therapeutic responses to immunotherapy.
- Strategies for manipulating gut microbiota include fecal microbial transplantation, probiotic supplementation, and dietary changes.
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