Full text is available at the source.
Abstract
Dysbiosis-associated shifts in microbial metabolite profiles are strongly associated with insulin resistance and chronic low-grade inflammation in type 2 diabetes.
- The gut-pancreas-metabolism axis links gut microbiota and pancreatic function in glucose regulation.
- Gut-derived bioactive metabolites influence insulin secretion and sensitivity, inflammation, and energy metabolism.
- Key regulatory pathways affected by these metabolites include AMP-activated protein kinase and PI3K/Akt signaling.
- Microbial metabolites may contribute to the preservation of pancreatic β-cells and overall metabolic balance.
- Therapeutic strategies such as probiotics and dietary modulation of the gut microbiome may support diabetes management.
Simplified