Nature reviews. Gastroenterology & hepatology

Expert advice on managing heart and liver health together in metabolic fatty liver disease

Updated

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) is linked to significant cardiovascular risks, with cardiovascular disease being a leading cause of death.

  • MASLD is increasingly recognized as a systemic metabolic disorder with implications for cardiovascular health.
  • Current diagnostic tools for MASLD, such as the fibrosis-4 index and vibration-controlled transient elastography, are available but not always utilized effectively.
  • Pharmacotherapies that benefit both liver and cardiovascular health are emerging, yet clinical management remains fragmented.
  • The overlap between cardiology and hepatology practices often leads to under-recognition of MASLD and its associated cardiovascular risks.
  • A multidisciplinary approach that includes early screening and coordinated management across specialties could improve outcomes for patients with MASLD.

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