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High-fat diet leads to adiposity and adipose tissue inflammation: the effect of whey protein supplementation and aerobic exercise training
High-fat diet causes fat gain and tissue inflammation, which may be reduced by whey protein and aerobic exercise
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Abstract
After 10 weeks of aerobic training and whey protein supplementation, both interventions reduced fat pad weight and inflammation markers in rats fed a high-fat diet.
- A high-fat diet significantly increased body weight, adiposity index, fat pad weight, glucose levels, and insulin resistance compared to a normal diet.
- Levels of inflammation markers TNF-α, MCP-1, HIF-1α, and VEGF-A were elevated in the adipose tissue of rats on a high-fat diet.
- Whey protein supplementation reduced glucose levels, insulin resistance index, and triglycerides independently of aerobic training.
- Both aerobic training and whey protein led to reductions in fat pad weight and levels of TNF-α, HIF-1α, and VEGF-A in adipose tissue.
- No significant reductions in MCP-1 levels in adipose tissue or serum TNF-α and MCP-1 were observed with either intervention.
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