Full text is available at the source.
Human milk oligosaccharide 2′-fucosyllactose alleviates cognitive impairment via the vagal afferent pathway in Alzheimer's disease mice
Human milk sugar 2'-fucosyllactose reduces memory problems through the nerve pathway to the brain in Alzheimer’s mice
AI simplified
Abstract
Oral administration of 2'-fucosyllactose (2'-FL) at doses of 500 and 1000 mg kg improved cognitive deficits in Alzheimer’s disease model mice.
- 2'-FL reduced β-amyloid deposition and neuroinflammation in the mice.
- The treatment improved spatial and recognition memory, suggesting cognitive benefits.
- Enhancement of c-Fos expression in the solitary tract nucleus indicated increased vagus nerve activity.
- Vagotomy demonstrated that the cognitive improvement from 2'-FL relied on the vagus nerve.
- 2'-FL improved gut barrier function and decreased gut inflammation.
- Alterations in gut microbiota composition and increased production of short-chain fatty acids (SCFAs) were observed with 2'-FL treatment.
AI simplified